https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1393 Sat 24 Mar 2018 08:28:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1396 Sat 24 Mar 2018 08:28:01 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1392 Sat 24 Mar 2018 08:27:59 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12192 br) and conductance (C_br), bronchial circumference (Circ_br) and wall thickness (Th_br). In Protocol 1 (P1), four sheep ran duplicate 5 min protocols on a horizontal treadmill at continuous step-up-and-down speeds of 1 min duration, namely, 0.8, 1.6, 2.2, 1.6 and 0.8 mph (moderate exercise), followed by 10 min recovery. In P2, four sheep ran duplicate 2 min protocols at constant 4 mph (strenuous exercise), and in P3, one sheep ran duplicate protocols each of 3 min at 2.2, 4.4 and 6 mph (severe exercise). Regression analysis and repeated measures ANOVA were used to assess differences between times, runs and exercise intensity. In P1, airway effects were directly related to graded exercise effort sustained over 5 min. Peak effects occurred at 2.2 mph, except for Th_br. Heart rate and Pa rose (to 156% and 111% of resting, respectively), and Q_br and C_br fell (to 83% and 75%; both P<0.001). Circ_br fell to 96% (P=0.02), and Th_br rose at low speeds early and late, and thinned at the highest speed. In P2 and P3 for all variables the steady-state effects were systematically greater than for P1 (4.4 mph: Cbr to 43%, Circ_br to 93%; 6.6 mph: C_br to 25%, Circ_br to 82%). There was no significant recovery hyperaemia, but there was residual post-exercise bronchoconstriction. The exercise stimulus–response relationships from rest to a maximal 6 mph for sheep airway circumference and its bronchial circulation are inverse and functionally constrictor.]]> Sat 24 Mar 2018 08:08:28 AEDT ]]>